150 Beach Road, #25-02 Gateway West, Singapore 189720.
Phone : +65 6392 2643
Email : sales@ymc.sg
150 Beach Road, #25-02 Gateway West, Singapore 189720.
Phone : +65 6392 2643
Email : sales@ymc.sg

Contichrom CUBE

Contichrom CUBE

Contichrom CUBE is a lab-scale twin-column chromatography system for continuous chromatography which offers several advantages over the traditional single-column chromatography:

  • minimal consumption of affinity resins for capture of antibodies
  • increased purity and productivity plus decreased solvent consumption in the purification of biopharmaceuticals, peptides and oligonucleotides
  • time- and space-saving for purification of biopharmaceuticals
  • minimal product waste from the crude materials
Catalogue Download Link
Catalogue Download Link
Catalogue Download Link
Contichrom CUBE 30
Catalogue Download Link
Catalogue Download Link
Catalogue Download Link
Contichrom CUBE 100
Catalogue Download Link
Catalogue Download Link
Catalogue Download Link
Contichrom CUBE 30
Catalogue Download Link
Catalogue Download Link
Catalogue Download Link
Contichrom CUBE 100
Column care and use instruction download link

Contichrom CUBE

Contichrom CUBE is a lab-scale twin-column chromatography system for continuous chromatography which offers several advantages over the traditional single-column chromatography:

  • minimal consumption of affinity resins for capture of antibodies
  • increased purity and productivity plus decreased solvent consumption in the purification of biopharmaceuticals, peptides and oligonucleotides
  • time- and space-saving for purification of biopharmaceuticals
  • minimal product waste from the crude materials
Catalogue Download Link
Catalogue Download Link
Catalogue Download Link
Contichrom CUBE 30
Catalogue Download Link
Catalogue Download Link
Catalogue Download Link
Contichrom CUBE 100
Column care and use instruction download link

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Specification:

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Contichrom CUBE 30 Contichrom CUBE 100

Pressure limit (MPa)

 10
Usable flow rate range (mL/min) 0.1-36 0.1-100
Continuous chromatography processes Select from MCSGP, N-Rich, CaptureSMB and Integrated Batch
(multiple selects allowed)
Pumps Double-head pumps (with seal wash)
4
Inlet valves 8x2+2
Outlet valves 4
Valves 2 Buffer selection valves, 4 Column valves, 2 Drain valves
System Dimensions
W×D×H (mm）		 509×450×584
Weight 47 kg
UV detector 2 fixed wavelengths, 280, 300 nm recorded simultaneously x 2
Conductivity sensor 1-300 mS/cm x2
pH sensor pH measurements 1-14
Device control Laptop computer (Windows, 64 bit, full HD resolution, 1920x1080 or higher)
Operating software ChromIQ® operating software
Supporting 21CFR Part11 Compliance
Wetted parts materials PEEK、PTFE
Others Cold room compatible
Portable & compact
Inline dilution capability

* Contichrome TWIN HPLC/LPLC system is also available for scale-up to industrial scale.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

Unique continuous purification processes

Contichrom CUBE offers a range of capabilities for different applications:

  • MCSGP with AutoPeak™ dynamic process control: continuous polishing for difficult separation challenges (oligonucleotides, peptides, multi-specific antibodies)
  • N-Rich: automated enrichment and isolation of product-related impurities
  • CaptureSMB with AutoMAb™ control and optimization: continuous capture of antibodies and tagged proteins for high resin utilization, low buffer consumption, and high productivity
  • Standard batch and integrated batch with in-line dilution

 

MCSGP N-Rich
  • Internally recycling the impure product-containing side fractions while continuously loading fresh feed and discarding impurities
  • Higher yield and purity
  • Automated isolation of minor components and product-related impurities overnight

 

CaptureSMB Integrated Batch
  • Increase in throughput with better utilization of affinity resins
  • Connecting two orthogonal batch steps
  • Running two process steps consecutively with inline dilution, and sparing a time-consuming ‘holding’ step

 

Applications

  1. IEX purification of oligonucleotide with MCSGP.
    1.5 times yield compared to single column batch purification. (56%→92%)
  2. RP purification of peptide with MCSGP.
    1.3 times yield compared to single column batch purification. (71%→92%)
  3. IEX purification of monoclonal antibody isoforms with N-Rich.
    10 times faster than single column batch purification.
  4. Affinity purification of monoclonal antibody with CaptureSMB.
    3 times efficiency compared to single column batch purification.

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YMC Singapore Tradelinks Pte. Ltd.

  • 150 Beach Road, #25-02 Gateway West, Singapore 189720.

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YMC Singapore Tradelinks Pte. Ltd.

  • 150 Beach Road, #25-02 Gateway West, Singapore 189720.

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© 2022 YMC. All rights reserved.

Designed by Wondertabs

  • Technical Support
  • Download
  • Selection Guide
  • Application Note
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Company Info

Product Category

YMC Singapore Tradelinks Pte. Ltd.

  • 150 Beach Road, #25-02 Gateway West, Singapore 189720.

Newsletter

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© 2022 YMC. All rights reserved.

Designed by Wondertabs

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YMC Singapore Tradelinks Pte. Ltd.

  • 150 Beach Road, #25-02 Gateway West, Singapore 189720.
© 2022 YMC. All rights reserved. | Designed by Wondertabs
  • 150 Beach Road, #25-02 Gateway West, Singapore 189720.

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Company Info

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Tel : +65 6392 2643

Fax : +65 6392 2856

Email : sales@ymc.sg

YMC Singapore Tradelinks Pte. Ltd.

150 Beach Road, #25-02 Gateway West, Singapore 189720.

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