This high purity porous silica provides high sample loading and high mechanical strength. YMC-Pack SIL is suitable for separation of oil-soluble compounds using non-polar mobile phases, as well as the separation of positional isomers that are difficult to separate in reversed-phase mode. SIL-06 (60Å) has greater adsorption properties than SIL (120Å) due to its larger surface area, and is generally useful for separating natural products with low molecular weight.